… Starting from these premises, our group designed PEGylated phenothiazine derivatives
as new building blocks for anticancer drugs. PEG has been bonded to the phenothiazine …

… into researcher attention another potential anticancer mechanism, that is, inhibition of
enzymes with a key role in tumor cell proliferation, such as farnesyltransferase [26,29,30,31]. …

… The bivalent compound 8 containing guanidine was synthesized with FTI-276, and biological
evaluation showed that the methyl ester form compound 8b could inhibit the formation of …

… The review included the extract of the studies in the past twenty years that were
performed globally, specifically on the synthesis and biological assessment of N-acylphenothiazines. …

… 5) 12a as an FTase inhibitor at the micromolar range. The same research group synthesized
a series of phenothiazine-1,2,3-triazole hybrids as FTase inhibitors (FTIs) with potential anti…

Theoretical and experimental data concerning the versatile approaches for the synthesis of
N-acylphenothiazines were systematized in this review. The aim of this research was to …

… inhibitor of CAAX based compounds has been synthesized … Phenothiazine containing scaffold
with cysteine residue was … be the most promising inhibitor of human farnesyltransferase. It …

… A new family of protein farnesyltransferase inhibitors, based on a phenothiazine containing
pyrazole scaffold, was synthesized and evaluated for their antiproliferative activity on a NCI-…

… phenothiazine containing … phenothiazine containing an ester unit (coded PPO) was prepared
by an esterification reaction of the phenothiazine acetic acid intermediate. Their synthesis …

… Tricyclic phenothiazine-containing drugs are currently used as an antidepressant and have
additionally exhibited antimicrobial activity [84]. Some phenothiazines demonstrated inhibi…